Molecular Signatures of Regression of the Canine Transmissible Venereal Tumor

Abstract excerpt

The canine transmissible venereal tumor (CTVT) is a clonally transmissible cancer that regresses spontaneously or after treatment with vincristine, but we know little about the regression mechanisms. We performed global transcriptional, methylation, and functional pathway analyses on serial biopsies of vincristine-treated CTVTs and found that regression occurs in sequential steps; activation of the innate immune...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Microbial infections and disease research
• Share to Veterinary Oncology Research
• Share to Virus-based gene therapy research