Article
The cyanobacterial ornithine-ammonia cycle involves an arginine dihydrolase.
Nature chemical biology - 1 Jun 2018
Zhang Hao, Liu Yujie, Nie Xiaoqun, Liu Lixia, Hua Qiang, Zhao Guo-Ping, Yang Chen
Abstract excerpt
Living organisms have evolved mechanisms for adjusting their metabolism to adapt to environmental nutrient availability. Terrestrial animals utilize the ornithine-urea cycle to dispose of excess nitrogen derived from dietary protein. Here, we identified an active ornithine-ammonia cycle (OAC) in cyanobacteria through an approach combining dynamic 15N and 13C tracers, metabolomics, and mathematical modeling. The...
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