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Article

STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle

9 Apr 2018

Abstract excerpt

Human papillomaviruses (HPV) activate a number of host factors to control their differentiation-dependent life cycles. The transcription factor signal transducer and activator of transcription (STAT)-3 is important for cell cycle progression and cell survival in response to cytokines and growth factors. STAT3 requires phosphorylation on Ser727, in addition to phosphorylation on Tyr705 to be transcriptionally...

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PMID: 29630659
DOI: 10.1371/journal.ppat.1006975

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