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Article

Rapid selection of sulphadoxine-resistant Plasmodium falciparum and its effect on within-population genetic diversity in Papua New Guinea.

Scientific reports - 3 Apr 2018

Mita Toshihiro, Hombhanje Francis, Takahashi Nobuyuki, Sekihara Makoto, Yamauchi Masato, Tsukahara Takahiro, Kaneko Akira, Endo Hiroyoshi, Ohashi Jun

Abstract excerpt

The ability of the human malarial parasite Plasmodium falciparum to adapt to environmental changes depends considerably on its ability to maintain within-population genetic variation. Strong selection, consequent to widespread antimalarial drug usage, occasionally elicits a rapid expansion of drug-resistant isolates, which can act as founders. To investigate whether this phenomenon induces a loss of...

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Identifiers

PMID: 29615786
DOI: 10.1038/s41598-018-23811-7
PMCID: PMC5882878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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