Article
Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis.
Blood - 7 Jun 2018
Liao Chang, Hardison Ross C, Kennett Mary J, Carlson Bradley A, Paulson Robert F, Prabhu K Sandeep
Abstract excerpt
Micronutrient selenium (Se) plays a key role in redox regulation through its incorporation into selenoproteins as the 21st amino acid selenocysteine (Sec). Because Se deficiency appears to be a cofactor in the anemia associated with chronic inflammatory diseases, we reasoned that selenoproteins may contribute to erythropoietic recovery from anemia, referred to as stress erythropoiesis. Here, we report that loss...
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