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Cyclic Cystine-Bridged Peptides from the Marine Sponge Clathria basilana Induce Apoptosis in Tumor Cells and Depolarize the Bacterial Cytoplasmic Membrane

2 Nov 2017

Abstract excerpt

Investigation of the sponge Clathria basilana collected in Indonesia afforded five new peptides, including microcionamides C ( 1 ) and D ( 2 ), gombamides B ( 4 ), C ( 5 ), and D ( 6 ), and an unusual amide, ( E )-2-amino-3-methyl- N -styrylbutanamide ( 7 ), along with 11 known compounds, among them microcionamide A ( 3 ). The structures of the new compounds were elucidated by one- and two-dimensional NMR...

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PMID: 29094598
DOI: 10.1021/acs.jnatprod.7b00477

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