Article
Chronic Myelomonocytic Leukemia With Fibrosis Is a Distinct Disease Subset With Myeloproliferative Features and Frequent JAK2 p.V617F Mutations.
The American journal of surgical pathology - 1 Jun 2018
Gur Hatice D, Loghavi Sanam, Garcia-Manero Guillermo, Routbort Mark, Kanagal-Shamanna Rashmi, Quesada Andres, Khogeer Haitham, Pierce Sherry, Medeiros L Jeffrey, Kantarjian Hagop, Khoury Joseph D
Abstract excerpt
A subset of patients with chronic myelomonocytic leukemia (CMML) presents with significance myelofibrosis. In myelodysplastic syndromes, significant myelofibrosis has been associated with adverse outcomes and p53 dysregulation. However, in CMML the clinical and molecular correlates of significant myelofibrosis at presentation remain poorly understood. From a cohort of 651 CMML patients, we identified...
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