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Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression

28 Mar 2018

Abstract excerpt

Genomic loss of 5-hydroxymethylcytosine (5hmC) accompanies malignant cellular transformation in breast cancer. Vitamin C serves as a cofactor for TET methylcytosine dioxygenases to increase 5hmC generation. Here we show that the transcription of SVCT2, a major vitamin C transporter, was decreased in human breast cancers (113 cases) compared to normal breast tissues from the same patients. A decreased SVCT2...

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PMID: 29593282
DOI: 10.1038/s41598-018-23714-7

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