Article
Translocation of a gut pathobiont drives autoimmunity in mice and humans.
Science (New York, N.Y.) - 9 Mar 2018
Manfredo Vieira S, Hiltensperger M, Kumar V, Zegarra-Ruiz D, Dehner C, Khan N, Costa F R C, Tiniakou E, Greiling T, Ruff W, Barbieri A, Kriegel C, Mehta S S, Knight J R, Jain D, Goodman A L, Kriegel M A
Abstract excerpt
Despite multiple associations between the microbiota and immune diseases, their role in autoimmunity is poorly understood. We found that translocation of a gut pathobiont, Enterococcus gallinarum, to the liver and other systemic tissues triggers autoimmune responses in a genetic background predisposing to autoimmunity. Antibiotic treatment prevented mortality in this model, suppressed growth of E. gallinarum in...
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