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Revisiting the Hygiene Hypothesis in the Context of Autoimmunity

28 Jan 2021

Abstract excerpt

Initially described for allergic diseases, the hygiene hypothesis was extended to autoimmune diseases in the early 2000s. A historical overview allows appreciation of the development of this concept over the last two decades and its discussion in the context of evolution. While the epidemiological data are convergent, with a few exceptions, the underlying mechanisms are multiple and complex. A major question is...

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PMID: 33584703
DOI: 10.3389/fimmu.2020.615192

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