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Article

Frontotemporal Dementia and Chorea Associated with a Compound Heterozygous TREM2 Mutation.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Redaelli Veronica, Salsano Ettore, Colleoni Lara, Corbetta Paola, Tringali Giovanni, Del Sole Angelo, Giaccone Giorgio, Rossi Giacomina

Abstract excerpt

Frontotemporal dementia (FTD) is clinically characterized by behavioral changes, language impairment, and executive dysfunction. FTD usually belongs to the frontotemporal lobar degeneration (FTLD) disease group, and its familial forms are dominantly inherited and linked to a group of genes relevant to frontal and temporal brain pathology, such as MAPT, GRN, C9ORF72, TARDBP, CHMP2B, VCP, and FUS. However, FTD can...

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Source

Identifiers

PMID: 29578490
DOI: 10.3233/JAD-180018

Genes

TREM2
FUS
GRN
MAPT
TARDBP
VCP

Provenance

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