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Article

False-Positive Plasma Genotyping Due to Clonal Hematopoiesis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2018

Hu Yuebi, Ulrich Bryan C, Supplee Julianna, Kuang Yanan, Lizotte Patrick H, Feeney Nora B, Guibert Nicolas M, Awad Mark M, Wong Kwok-Kin, Jänne Pasi A, Paweletz Cloud P, Oxnard Geoffrey R

Abstract excerpt

Purpose: Plasma cell-free DNA (cfDNA) genotyping is increasingly used in cancer care, but assay accuracy has been debated. Because most cfDNA is derived from peripheral blood cells (PBC), we hypothesized that nonmalignant mutations harbored by hematopoietic cells (clonal hematopoiesis, CH) could be a cause of false-positive plasma genotyping.Experimental Design: We identified patients with advanced non-small cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29567812
DOI: 10.1158/1078-0432.CCR-18-0143

Genes

KRAS
JAK2
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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