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Article

Discrimination of Germline EGFR T790M Mutations in Plasma Cell-Free DNA Allows Study of Prevalence Across 31,414 Cancer Patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2017

Hu Yuebi, Alden Ryan S, Odegaard Justin I, Fairclough Stephen R, Chen Ruthia, Heng Jennifer, Feeney Nora, Nagy Rebecca J, Shah Jayshree, Ulrich Bryan, Gutierrez Martin, Lanman Richard B, Garber Judy E, Paweletz Cloud P, Oxnard Geoffrey R

Abstract excerpt

Purpose: Plasma cell-free DNA (cfDNA) analysis is increasingly used clinically for cancer genotyping, but may lead to incidental identification of germline-risk alleles. We studied EGFR T790M mutations in non-small cell lung cancer (NSCLC) toward the aim of discriminating germline and cancer-derived variants within cfDNA.Experimental Design: Patients with EGFR-mutant NSCLC, some with known germline EGFR T790M,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28947568
DOI: 10.1158/1078-0432.CCR-17-1745
PMCID: PMC5712272

Genes

EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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