Article
Measuring and Estimating the Effect Sizes of Copy Number Variants on General Intelligence in Community-Based Samples.
JAMA psychiatry - 1 May 2018
Huguet Guillaume, Schramm Catherine, Douard Elise, Jiang Lai, Labbe Aurélie, Tihy Frédérique, Mathonnet Géraldine, Nizard Sonia, Lemyre Emmanuelle, Mathieu Alexandre, Poline Jean-Baptiste, Loth Eva, Toro Roberto, Schumann Gunter, Conrod Patricia, Pausova Zdenka, Greenwood Celia, Paus Tomas, Bourgeron Thomas, Jacquemont Sébastien
Abstract excerpt
Importance;: Copy number variants (CNVs) classified as pathogenic are identified in 10% to 15% of patients referred for neurodevelopmental disorders. However, their effect sizes on cognitive traits measured as a continuum remain mostly unknown because most of them are too rare to be studied individually using association studies. Objective: To measure and estimate the effect sizes of recurrent and nonrecurrent...
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