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Article

Previously reported placebo-response-associated variants do not predict patient outcomes in inflammatory disease Phase III trial placebo arms.

Genes and immunity - 1 Feb 2019

Haug-Baltzell Asher, Bhangale Tushar R, Chang Diana, Dressen Amy, Yaspan Brian L, Ortmann Ward, Brauer Matthew J, Hunkapiller Julie, Reeder Jens, Mukhyala Kiran, Cuenco Karen T, Tom Jennifer A, Cowgill Amy, Vogel Jan, Forrest William F, Behrens Timothy W, Graham Robert R, Wuster Arthur

Abstract excerpt

In clinical trials, a placebo response refers to improvement in disease symptoms arising from the psychological effect of receiving a treatment rather than the actual treatment under investigation. Previous research has reported genomic variation associated with the likelihood of observing a placebo response, but these studies have been limited in scope and have not been validated. Here, we analyzed whole-genome...

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Identifiers

PMID: 29550837
DOI: 10.1038/s41435-018-0018-z
PMCID: PMC6515143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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