Article
D-2-Hydroxyglutarate Is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant-Induced MIR148A Promoter Methylation.
Molecular cancer research : MCR - 1 Jun 2018
Li Tie, Cox Christopher D, Ozer Byram H, Nguyen Nhung T, Nguyen HuyTram N, Lai Thomas J, Li Sichen, Liu Fei, Kornblum Harley I, Liau Linda M, Nghiemphu Phioanh L, Cloughesy Timothy F, Lai Albert
Abstract excerpt
Mutant isocitrate dehydrogenase (IDH) 1/2 converts α-ketoglutarate (α-KG) to D-2 hydroxyglutarate (D-2-HG), a putative oncometabolite that can inhibit α-KG-dependent enzymes, including ten-eleven translocation methylcytosine dioxygenase (TET) DNA demethylases. We recently established that miRNAs are components of the IDH1 mutant-associated glioma CpG island methylator phenotype (G-CIMP) and specifically...
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