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Article

Nimbus: a design-driven analyses suite for amplicon-based NGS data.

Bioinformatics (Oxford, England) - 15 Aug 2018

Brouwer R W W, van den Hout M C G N, Kockx C E M, Brosens E, Eussen B, de Klein A, Sleutels F, van IJcken W F J

Abstract excerpt

Motivation: PCR-based DNA enrichment followed by massively parallel sequencing is a straightforward and cost effective method to sequence genes up to high depth. The full potential of amplicon-based sequencing assays is currently not achieved as analysis methods do not take into account the source amplicons of the detected variants. Tracking the source amplicons has the potential to identify systematic biases,...

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Identifiers

PMID: 29538618
DOI: 10.1093/bioinformatics/bty145
PMCID: PMC6084620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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