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Article

Clinical application of targeted next-generation sequencing in fetuses with congenital heart defect.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology - 1 Aug 2018

Hu P, Qiao F, Wang Y, Meng L, Ji X, Luo C, Xu T, Zhou R, Zhang J, Yu B, Wang L, Wang T, Pan Q, Ma D, Liang D, Xu Z

Abstract excerpt

OBJECTIVES: To assess the value of targeted next-generation sequencing (NGS) in prenatal diagnosis of congenital heart defects (CHD) and to investigate the genetic etiology of prenatal CHD. METHODS: Forty-four fetuses with CHD, normal molecular karyotype and negative chromosomal microarray results underwent targeted NGS. Fetal genomic DNA was extracted directly from amniotic fluid cells in each prenatal case. A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29536580
DOI: 10.1002/uog.19042

Genes

CHD7
CITED2
JAG1
MYH6
ZFPM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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