Article
Application of high-throughput sequencing for studying genomic variations in congenital heart disease.
Briefings in functional genomics - 1 Jan 2014
Dorn Cornelia, Grunert Marcel, Sperling Silke R
Abstract excerpt
Congenital heart diseases (CHD) represent the most common birth defect in human. The majority of cases are caused by a combination of complex genetic alterations and environmental influences. In the past, many disease-causing mutations have been identified; however, there is still a large proportion of cardiac malformations with unknown precise origin. High-throughput sequencing technologies established during...
Topics
- Databases, Genetic
- Genetic Association Studies
- Genetic Variation
- Genomics
- Heart Defects, Congenital
- High-Throughput Nucleotide Sequencing
- Humans