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Article

Exosome-Based Detection of EGFR T790M in Plasma from Non-Small Cell Lung Cancer Patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2018

Castellanos-Rizaldos Elena, Grimm Dominik G, Tadigotla Vasisht, Hurley James, Healy John, Neal Patricia L, Sher Mia, Venkatesan Raajdeep, Karlovich Chris, Raponi Mitch, Krug Anne, Noerholm Mikkel, Tannous Jihane, Tannous Bakhos A, Raez Luis E, Skog Johan K

Abstract excerpt

Purpose: About 60% of non-small cell lung cancer (NSCLC) patients develop resistance to targeted epidermal growth factor receptor (EGFR) inhibitor therapy through the EGFR T790M mutation. Patients with this mutation respond well to third-generation tyrosine kinase inhibitors, but obtaining a tissue biopsy to confirm the mutation poses risks and is often not feasible. Liquid biopsies using circulating free tumor...

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PMID: 29535126
DOI: 10.1158/1078-0432.CCR-17-3369

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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