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Article

Why West? Comparisons of clinical, genetic and molecular features of infants with and without spasms

8 Mar 2018

Abstract excerpt

Infantile spasms are the defining seizures of West syndrome, a severe form of early life epilepsy with poorly-understood pathophysiology. We present a novel comparative analysis of infants with spasms versus other seizure-types and identify clinical, etiological, and molecular-genetic factors preferentially predisposing to spasms. We compared ages, clinical etiologies, and associated-genes between spasms and...

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PMID: 29518120
DOI: 10.1371/journal.pone.0193599

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