Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The origins of breast cancer associated with mammographic density: a testable biological hypothesis.

Breast cancer research : BCR - 7 Mar 2018

Boyd Norman, Berman Hal, Zhu Jie, Martin Lisa J, Yaffe Martin J, Chavez Sofia, Stanisz Greg, Hislop Greg, Chiarelli Anna M, Minkin Salomon, Paterson Andrew D

Abstract excerpt

BACKGROUND: Our purpose is to develop a testable biological hypothesis to explain the known increased risk of breast cancer associated with extensive percent mammographic density (PMD), and to reconcile the apparent paradox that although PMD decreases with increasing age, breast cancer incidence increases. METHODS: We used the Moolgavkar model of carcinogenesis as a framework to examine the known biological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Breast

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Density

Share to Breast Neoplasms

Share to Epithelial Cells

Share to Fibroblasts

Share to Mammography

Share to Menopause

Source

Open in PubMed Open full text

Identifiers

PMID: 29514672
DOI: 10.1186/s13058-018-0941-y
PMCID: PMC5842598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The origins of breast cancer associated with mammographic density: a testable biological hypothesis.PMID 29514672Read ↗

Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: hypotheses based on epidemiological evidence.Semantic proximity Read ↗

Breast tissue composition and susceptibility to breast cancer.Semantic proximity Read ↗

Mammographic breast density as an intermediate phenotype for breast cancer.Semantic proximity Read ↗

Heritability of Mammographic Breast Density, Density Change, Microcalcifications, and Masses.Semantic proximity Read ↗

Genetic architecture of mammographic density as a risk factor for breast cancer: a systematic review.Semantic proximity Read ↗

Mammographic density, pathogenic breast cancer susceptibility gene variants and breast cancer riskSemantic proximity Read ↗

High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium.Semantic proximity Read ↗

Common genetic variants associated with breast cancer and mammographic density measures that predict disease.Semantic proximity Read ↗

Raised mammographic density: causative mechanisms and biological consequences.Semantic proximity Read ↗

Mammographic breast density and breast cancer: evidence of a shared genetic basis.Semantic proximity Read ↗

Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk.Semantic proximity Read ↗

Mammographic density mediates the protective effect of early-life body size on breast cancer risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.