MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques.

doi:10.1073/pnas.1722106115

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Article

MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques.

Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2018

Brammer David W, Gillespie Patrick J, Tian Mei, Young Daniel, Raveendran Muthuswamy, Williams Lawrence E, Gagea Mihai, Benavides Fernando J, Perez Carlos J, Broaddus Russell R, Bernacky Bruce J, Barnhart Kirstin F, Alauddin Mian M, Bhutani Manoop S, Gibbs Richard A, Sidman Richard L, Pasqualini Renata, Arap Wadih, Rogers Jeffrey, Abee Christian R, Gelovani Juri G

Abstract excerpt

Over the past two decades, 33 cases of colonic adenocarcinomas have been diagnosed in rhesus macaques (Macaca mulatta) at the nonhuman primate colony of the Keeling Center for Comparative Medicine and Research at The University of Texas MD Anderson Cancer Center. The distinctive feature in these cases, based on PET/computed tomography (CT) imaging, was the presence of two or three tumor lesions in different...

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Identifiers

PMID: 29490919
DOI: 10.1073/pnas.1722106115
PMCID: PMC5856559

Genes

MLH1
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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