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Article

The Myth of Optimality in Clinical Neuroscience.

Trends in cognitive sciences - 1 Mar 2018

Holmes Avram J, Patrick Lauren M

Abstract excerpt

Clear evidence supports a dimensional view of psychiatric illness. Within this framework the expression of disorder-relevant phenotypes is often interpreted as a breakdown or departure from normal brain function. Conversely, health is reified, conceptualized as possessing a single ideal state. We challenge this concept here, arguing that there is no universally optimal profile of brain functioning. The...

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Identifiers

PMID: 29475637
DOI: 10.1016/j.tics.2017.12.006
PMCID: PMC5829018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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