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Article

The Conundrum of "Warfarin Hypersensitivity": Prolonged Partial Thromboplastin Time From Factor IX Propeptide Mutation.

American journal of therapeutics - 1 Jan 2000

Sekhri Arunabh, Lisinschi Adriana, Furqan Muhammad, Palaniswamy Chandrasekar, Mukhi Nikhil, Gupta Ridhi, Nelson John C

Abstract excerpt

Carboxylation of glutamic acid residues of vitamin K dependent clotting factors (II, VII, IX, and X) is essential to their biological functioning. Binding of these factors to γ-glutamyl carboxylase enzyme for carboxylation reaction is mediated by wild-type propeptide, a small sequence of amino ac...

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Identifiers

PMID: 24832385
DOI: 10.1097/MJT.0000000000000077

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24832385-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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