Article
An allogeneic 'off the shelf' therapeutic strategy for peripheral nerve tissue engineering using clinical grade human neural stem cells.
Scientific reports - 13 Feb 2018
O'Rourke C, Day A G E, Murray-Dunning C, Thanabalasundaram L, Cowan J, Stevanato L, Grace N, Cameron G, Drake R A L, Sinden J, Phillips J B
Abstract excerpt
Artificial tissues constructed from therapeutic cells offer a promising approach for improving the treatment of severe peripheral nerve injuries. In this study the effectiveness of using CTX0E03, a conditionally immortalised human neural stem cell line, as a source of allogeneic cells for constructing living artificial nerve repair tissue was tested. CTX0E03 cells were differentiated then combined with collagen...
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