Article
Next-Generation Sequencing and Bioinformatics Protocol for Malaria Drug Resistance Marker Surveillance.
Antimicrobial agents and chemotherapy - 1 Apr 2018
Talundzic Eldin, Ravishankar Shashidhar, Kelley Julia, Patel Dhruviben, Plucinski Mateusz, Schmedes Sarah, Ljolje Dragan, Clemons Brooke, Madison-Antenucci Susan, Arguin Paul M, Lucchi Naomi W, Vannberg Fredrik, Udhayakumar Venkatachalam
Abstract excerpt
The recent advances in next-generation sequencing technologies provide a new and effective way of tracking malaria drug-resistant parasites. To take advantage of this technology, an end-to-end Illumina targeted amplicon deep sequencing (TADS) and bioinformatics pipeline for molecular surveillance of drug resistance in P. falciparum, called malaria resistance surveillance (MaRS), was developed. TADS relies on PCR...
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