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Article

Comprehensive review of genetic factors contributing to head and neck squamous cell carcinoma development in low-risk, nontraditional patients.

Head & neck - 1 May 2018

Gingerich Morgan A, Smith Joshua D, Michmerhuizen Nicole L, Ludwig Megan, Devenport Samantha, Matovina Chloe, Brenner Chad, Chinn Steven B

Abstract excerpt

BACKGROUND: The past 2 decades have seen an increased incidence of head and neck squamous cell carcinoma (HNSCC) in a nontraditional, low-risk patient population (ie, ≤45 years of age, no substance use history), owing to a combination of human papillomavirus (HPV) infection and individual genetic variation. METHODS: Articles positing genetic variants as contributing factors in HNSCC incidence in low-risk,...

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Identifiers

PMID: 29427520
DOI: 10.1002/hed.25057
PMCID: PMC5912962

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