Icon immunoconjugate treatment results in regression of red lesions in a non-human primate (Papio anubis) model of endometriosis.

doi:10.1016/j.repbio.2018.01.009

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Icon immunoconjugate treatment results in regression of red lesions in a non-human primate (Papio anubis) model of endometriosis.

Reproductive biology - 1 Mar 2018

Hufnagel Demetra, Goetz Teddy G, Hu Zhiwei, Nyachieo Atunga, D'Hooghe Thomas, Fazleabas Asgerally, Duleba Antoni, Krikun Graciela, Taylor Hugh S, Lockwood Charles J

Abstract excerpt

Endometriosis is a common condition in reproductive-aged women characterized by ectopic endometrial lesions of varied appearance, including red, white, blue, black or powder burn coloration, which contribute to chronic pain and infertility. The immunoconjugate molecule (Icon) targets Tissue Factor, a transmembrane receptor for Factor VII/VIIa that is aberrantly expressed in the endothelium supporting ectopic...

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Icon immunoconjugate treatment results in regression of red lesions in a non-human primate (Papio anubis) model of endometriosis.

Abstract excerpt

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