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[Data analysis of non-invasive prenatal testing based on special loci in cell-free fetal DNA].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 10 Feb 2018

Xuan Liming, Kong Lingyin, Xia Yingying, Mao Yan, Shen Jingjing, Zhu Yijun, Xue Yongfeng, Sun Danfeng, Liu Huimin, Liang Bo

Abstract excerpt

OBJECTIVE To analyze the data of non-invasive prenatal testing based on specific loci of circulating cell-free fetal DNA (cffDNA). METHODS Selected loci of target chromosomes were analyzed by sequence capture and sequencing. Meanwhile, 600 loci were selected from other chromosomes for determining the concentration of cffDNA. RESULTS A total of 768 specific loci were captured on chromosomes 21 and 18, and used to...

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Identifiers

PMID: 29419861
DOI: 10.3760/cma.j.issn.1003-9406.2018.01.012

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