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Article

High cripto-1 and low miR-205 expression levels as prognostic markers in early stage non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Feb 2018

Park Kang-Seo, Moon Yong Wha, Raffeld Mark, Lee Dae Ho, Wang Yisong, Giaccone Giuseppe

Abstract excerpt

OBJECTIVES: Cripto-1 (CR-1) plays a critical role in the activation of SMAD, SRC, and epithelial-to-mesenchymal transition (EMT) pathways and has been shown to be prognostic in several cancer types. In addition, we showed that CR-1 renders EGFR-mutated NSCLC cells resistant to EGFR-TKI through the activation of SRC and EMT via miR-205 downregulation. This study aimed to investigate the correlation between...

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Identifiers

PMID: 29413049
DOI: 10.1016/j.lungcan.2017.12.010
PMCID: PMC8057110

Genes

EGFR
SRC

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