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Article

CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance.

The Journal of clinical investigation - 1 Jul 2014

Park Kang-Seo, Raffeld Mark, Moon Yong Wha, Xi Liqiang, Bianco Caterina, Pham Trung, Lee Liam C, Mitsudomi Tetsuya, Yatabe Yasushi, Okamoto Isamu, Subramaniam Deepa, Mok Tony, Rosell Rafael, Luo Ji, Salomon David S, Wang Yisong, Giaccone Giuseppe

Abstract excerpt

The majority of non-small cell lung cancer (NSCLC) patients harbor EGFR-activating mutations that can be therapeutically targeted by EGFR tyrosine kinase inhibitors (EGFR-TKI), such as erlotinib and gefitinib. Unfortunately, a subset of patients with EGFR mutations are refractory to EGFR-TKIs. Re...

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Source

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Identifiers

PMID: 24911146
DOI: 10.1172/JCI73048
PMCID: PMC4071378

Genes

EGFR
SRC
ZEB1
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24911146-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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