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Article

Ibuprofen is deleterious for the development of first trimester human fetal ovary ex vivo

8 Jan 2018

Abstract excerpt

STUDY QUESTION: Does ibuprofen use during the first trimester of pregnancy interfere with the development of the human fetal ovary? SUMMARY ANSWER: In human fetuses, ibuprofen exposure is deleterious for ovarian germ cells. WHAT IS KNOWN ALREADY: In utero stages of ovarian development define the future reproductive capacity of a woman. In rodents, analgesics can impair the development of the fetal ovary leading...

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PMID: 29408962
DOI: 10.1093/humrep/dex383

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