Article
The truncated Rv2820c of Mycobacterium tuberculosis Beijing family augments intracellular survival of M. smegmatis by altering cytokine profile and inhibiting NO generation.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Apr 2018
Zhai Xiaoqian, Luo Tao, Peng Xuan, Ma Pengjiao, Wang Chuhan, Zhang Chunxi, Suo Jing, Bao Lang
Abstract excerpt
Genetic variations among genes of Mycobacterium tuberculosis may be associated with antigenic variation and immune evasion, which complicates the pathogenesis of M. tuberculosis. The hyper-virulent M. tuberculosis Beijing strains harbored several large sequence deletions, among which RD207 attributed to the deletion of CRISPR loci and several Cas genes. RD207 also gave rise to a truncated gene Rv2820c-Bj with 60%...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.