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Article

DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood

5 Jan 2018

Abstract excerpt

(adipogenesis). DNAm at the CpGs involved was associated with gene expression in an external data set and correlated with DNAm levels in fat depots in additional postmortem data. Our data are consistent with the hypothesis that epigenetic mechanisms mediate the influence of transient adverse environmental factors in early life on long-term metabolic health. The specific mechanism awaits elucidation.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29399631
DOI: 10.1126/sciadv.aao4364

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