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Article

Deciphering defective amelogenesis using in vitro culture systems.

Journal of bioscience and bioengineering - 1 Apr 2018

Arinawati Dian Yosi, Miyoshi Keiko, Tanimura Ayako, Horiguchi Taigo, Hagita Hiroko, Noma Takafumi

Abstract excerpt

The conventional two-dimensional (2D) in vitro culture system is frequently used to analyze the gene expression with or without extracellular signals. However, the cells derived from primary culture and cell lines frequently deviate the gene expression profile compared to the corresponding in vivo samples, which sometimes misleads the actual gene regulation in vivo. To overcome this gap, we developed the...

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PMID: 29397320
DOI: 10.1016/j.jbiosc.2017.11.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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