Article
Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher Disease.
EBioMedicine - 1 Feb 2018
Jian Jinlong, Chen Yuehong, Liberti Rossella, Fu Wenyu, Hu Wenhuo, Saunders-Pullman Rachel, Pastores Gregory M, Chen Ying, Sun Ying, Grabowski Gregory A, Liu Chuan-Ju
Abstract excerpt
We recently reported that progranulin (PGRN) is a novel regulator of glucocerebrosidase and its deficiency associates with Gaucher Diseases (GD) (Jian et al., 2016a; Jian et al., 2018). To isolate the relevant downstream molecules, we performed a whole genome microarray and mass spectrometry analysis, which led to the isolation of Chitinase-3-like-1 (CHI3L1) as one of the up-regulated genes in PGRN null mice....
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