Article
The Wnt/β‐catenin pathway determines the predisposition and efficiency of liver‐to‐pancreas reprogramming
2 Feb 2018
Abstract excerpt
Transdifferentiation (TD) is the direct reprogramming of adult cells into cells of alternate fate and function. We have previously shown that liver cells can be transdifferentiated into beta-like, insulin-producing cells through ectopic expression of pancreatic transcription factors (pTFs). However, the efficiency of the process was consistently limited to <15% of the human liver cells treated in culture. The...
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