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Article

Mapping the interaction site and effect of the Siglec-9 inflammatory biomarker on human primary amine oxidase.

Scientific reports - 1 Feb 2018

Lopes de Carvalho Leonor, Elovaara Heli, de Ruyck Jerôme, Vergoten Gerard, Jalkanen Sirpa, Guédez Gabriela, Salminen Tiina A

Abstract excerpt

Human primary amine oxidase (hAOC3), also known as vascular adhesion protein 1, mediates leukocyte rolling and trafficking to sites of inflammation by a multistep adhesion cascade. hAOC3 is absent on the endothelium of normal tissues and is kept upregulated during inflammatory conditions, which is an applicable advantage for imaging inflammatory diseases. Sialic acid binding immunoglobulin like-lectin 9...

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Identifiers

PMID: 29391504
DOI: 10.1038/s41598-018-20618-4
PMCID: PMC5794975

Genes

AOC3

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