Article
Analysis of bacterial genomes from an evolution experiment with horizontal gene transfer shows that recombination can sometimes overwhelm selection.
PLoS genetics - 1 Jan 2018
Maddamsetti Rohan, Lenski Richard E
Abstract excerpt
Few experimental studies have examined the role that sexual recombination plays in bacterial evolution, including the effects of horizontal gene transfer on genome structure. To address this limitation, we analyzed genomes from an experiment in which Escherichia coli K-12 Hfr (high frequency recombination) donors were periodically introduced into 12 evolving populations of E. coli B and allowed to conjugate...
Topics
- Base Sequence
- Conjugation, Genetic
- Directed Molecular Evolution
- Escherichia coli K12
- Evolution, Molecular
- Gene Transfer, Horizontal
- Genetic Variation
- Genome, Bacterial
- Recombination, Genetic
- Selection, Genetic
- Sequence Analysis, DNA