Article
Tumor-induced osteomalacia in association with PTEN-negative Cowden syndrome.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Apr 2018
Berglund J A, Gafni R I, Wodajo F, Cowen E W, El-Maouche D, Chang R, Chen C C, Guthrie L C, Molinolo A A, Collins M T
Abstract excerpt
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic condition in which phosphaturic mesenchymal tumors (PMTs) secrete high levels of fibroblast growth factor 23 (FGF23) into the circulation. This results in renal phosphate wasting, hypophosphatemia, muscle weakness, bone pain, and pathological fractures. Recent studies suggest that fibronectin-fibroblast growth factor receptor 1 (FN1-FGFR1) translocations...
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