Article
The nature of nurture: Effects of parental genotypes.
Science (New York, N.Y.) - 26 Jan 2018
Kong Augustine, Thorleifsson Gudmar, Frigge Michael L, Vilhjalmsson Bjarni J, Young Alexander I, Thorgeirsson Thorgeir E, Benonisdottir Stefania, Oddsson Asmundur, Halldorsson Bjarni V, Masson Gisli, Gudbjartsson Daniel F, Helgason Agnar, Bjornsdottir Gyda, Thorsteinsdottir Unnur, Stefansson Kari
Abstract excerpt
Sequence variants in the parental genomes that are not transmitted to a child (the proband) are often ignored in genetic studies. Here we show that nontransmitted alleles can affect a child through their impacts on the parents and other relatives, a phenomenon we call "genetic nurture." Using results from a meta-analysis of educational attainment, we find that the polygenic score computed for the nontransmitted...
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