Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prenatal Dexamethasone Exposure Induced Ovarian Developmental Toxicity and Transgenerational Effect in Rat Offspring.

Endocrinology - 1 Mar 2018

Lv Feng, Wan Yang, Chen Yunxi, Pei Linguo, Luo Daji, Fan Guanlan, Luo Mengcheng, Xu Dan, Wang Hui

Abstract excerpt

Prenatal dexamethasone exposure (PDE) induces multiorgan developmental toxicities in offspring. Here we verified the transgenerational inheritance effect of ovarian developmental toxicity by PDE and explored its intrauterine programming mechanism. Pregnant rats subcutaneously received 0.2 mg/kg/d dexamethasone from gestational day (GD) 9 to GD20. A subgroup was euthanized for fetuses on GD20, and the other group...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dexamethasone
Share to Estradiol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fetal Blood

Share to Prenatal Exposure Delayed Effects

Share to Specific Pathogen-Free Organisms

Share to Steroidogenic Factor 1

Share to Steroids

Source

Identifiers

PMID: 29370380
DOI: 10.1210/en.2018-00044

Genes

IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prenatal Dexamethasone Exposure Induced Ovarian Developmental Toxicity and Transgenerational Effect in Rat Offspring.PMID 29370380Read ↗

The miR-98-3p/JAG1/Notch1 axis mediates the multigenerational inheritance of osteopenia caused by maternal dexamethasone exposure in female rat offspringSemantic proximity Read ↗

Developmental toxicity and programming alterations of multiple organs in offspring induced by medication during pregnancySemantic proximity Read ↗

Gestational dexamethasone exposure impacts hippocampal excitatory synaptic transmission and learning and memory function with transgenerational effectsSemantic proximity Read ↗

Transgenerational Inheritance of Reproductive and Metabolic Phenotypes in PCOS Rats.Semantic proximity Read ↗

Prenatal exposure to dexamethasone in the mouse induces sex‐specific differences in placental gene expressionSemantic proximity Read ↗

Epigenetic programming mediates abnormal gut microbiota and disease susceptibility in offspring with prenatal dexamethasone exposureSemantic proximity Read ↗

Dose-, stage- and sex- difference of prenatal prednisone exposure on placental morphological and functional developmentSemantic proximity Read ↗

The role of miRNAs in regulating the effect of prenatal cadmium exposure on ovarian granulosa cells in a transgenerational manner in female ratsSemantic proximity Read ↗

Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats.Semantic proximity Read ↗

Dexamethasone and sex regulate placental glucocorticoid receptor isoforms in miceSemantic proximity Read ↗

Environmental toxicant induced epigenetic transgenerational inheritance of ovarian pathology and granulosa cell epigenome and transcriptome alterations: ancestral origins of polycystic ovarian syndrome and primary ovarian insufficiencySemantic proximity Read ↗

Vitamin D deficiency worsens maternal diabetes induced neurodevelopmental disorder by potentiating hyperglycemia‐mediated epigenetic changesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.