FOXK2 suppresses the malignant phenotype and induces apoptosis through inhibition of EGFR in clear-cell renal cell carcinoma.

doi:10.1002/ijc.31278

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Article

FOXK2 suppresses the malignant phenotype and induces apoptosis through inhibition of EGFR in clear-cell renal cell carcinoma.

International journal of cancer - 15 Jun 2018

Zhang Fan, Ma Xin, Li Hongzhao, Zhang Yu, Li Xintao, Chen Luyao, Guo Gang, Gao Yu, Gu Liangyou, Xie Yongpeng, Duan Junyao, Zhang Xu

Abstract excerpt

Forkhead box K2 (FOXK2) belongs to the forkhead box transcription factor family. Recent studies have revealed that FOXK2 plays essential roles in cancer cell proliferation and survival. However, the biological function of FOXK2 in renal cell carcinoma remains unexplored. In our study, we demonstrated that FOXK2 mRNA and protein levels were decreased in clear-cell renal cell carcinoma (ccRCC) tissues compared to...

Topics

Animals
Apoptosis
Biomarkers, Tumor
Carcinoma, Renal Cell
ErbB Receptors
Female
Forkhead Transcription Factors
Gene Expression Regulation, Neoplastic
Heterografts
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kaplan-Meier Estimate

Kidney Neoplasms

Male

Mice

Middle Aged

Phenotype

Prognosis

Source

Open in PubMed

Identifiers

PMID: 29368368
DOI: 10.1002/ijc.31278

Genes

FOXK2
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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