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Malignant Hyperthermia and Ryanodine Receptor Type 1 Gene (RyR1) Mutation in a Family in Singapore.

Annals of the Academy of Medicine, Singapore - 1 Dec 2017

Li Daphne Wy, Lai Poh San, Lee Delice W, Yong Rita Yy, Lee Tat Leang

Abstract excerpt

INTRODUCTION: Sporadic clinical episodes of malignant hyperthermia (MH) that develop during general anaesthesia (GA) have been reported in Singapore. However, there is no published local report of a confirmed case of MH susceptibility (MHS) by skeletal muscle contracture tests and/or molecular tests. MATERIALS AND METHODS: We report 2 patients from an extended family who developed signs of clinical MH while under...

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PMID: 29355282

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