Phenotypic analysis of HIV-1 E157Q integrase polymorphism and impact on virological outcome in patients initiating an integrase inhibitor-based regimen.

doi:10.1093/jac/dkx511

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Article

Phenotypic analysis of HIV-1 E157Q integrase polymorphism and impact on virological outcome in patients initiating an integrase inhibitor-based regimen.

The Journal of antimicrobial chemotherapy - 1 Apr 2018

Charpentier Charlotte, Malet Isabelle, Andre-Garnier Elisabeth, Storto Alexandre, Bocket Laurence, Amiel Corinne, Morand-Joubert Laurence, Tumiotto Camille, Nguyen Thuy, Maillard Anne, Rodallec Audrey, Leoz Marie, Montes Brigitte, Schneider Véronique, Plantier Jean-Christophe, Dina Julia, Pallier Coralie, Mirand Audrey, Roussel Catherine, Signori-Schmuck Anne, Raymond Stéphanie, Calvez Vincent, Delaugerre Constance, Marcelin Anne-Geneviève, Descamps Diane

Abstract excerpt

Objectives: To assess the phenotypic susceptibility of the E157Q polymorphism in HIV-1 integrase (IN) and the virological outcome of patients infected with E157Q-mutated virus initiating an IN inhibitor (INI)-based regimen. Methods: This was a multicentre study assessing IN sequences from INI-naive patients among 17 French HIV clinical centres. E157Q site-directed mutants in pNL4.3 and pCRF02_AG contexts were...

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PMID: 29342281
DOI: 10.1093/jac/dkx511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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