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Utility of ultra-deep sequencing for detection of varicella-zoster virus antiviral resistance mutations.

Antiviral research - 1 Mar 2018

Mercier-Darty Mélanie, Boutolleau David, Lepeule Raphaël, Rodriguez Christophe, Burrel Sonia

Abstract excerpt

We report the first application of ultra-deep sequencing (UDS) to varicella-zoster virus (VZV) genotypic antiviral testing in a case of acyclovir-resistant VZV infection initially detected by Sanger sequencing within a deeply immunocompromised heart transplant recipient. As added-value compared to Sanger analysis, UDS revealed complex dynamics of viral population under antiviral pressure. Varicella-zoster virus...

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PMID: 29337163
DOI: 10.1016/j.antiviral.2018.01.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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