Article
Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination.
Aging cell - 1 Oct 2011
Gomes Nuno M V, Ryder Oliver A, Houck Marlys L, Charter Suellen J, Walker William, Forsyth Nicholas R, Austad Steven N, Venditti Chris, Pagel Mark, Shay Jerry W, Wright Woodring E
Abstract excerpt
Progressive telomere shortening from cell division (replicative aging) provides a barrier for human tumor progression. This program is not conserved in laboratory mice, which have longer telomeres and constitutive telomerase. Wild species that do/do not use replicative aging have been reported, but the evolution of different phenotypes and a conceptual framework for understanding their uses of telomeres is...
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