Article
Next generation sequencing characterizes the extent of HLA diversity in an Argentinian registry population.
HLA - 1 Mar 2018
Hurley C K, Hou L, Lazaro A, Gerfen J, Enriquez E, Galarza P, Rodriguez Cardozo M B, Halagan M, Maiers M, Behm D, Ng J
Abstract excerpt
Next generation DNA sequencing is used to determine the HLA-A, -B, -C, -DRB1, and -DQB1 assignments of 1472 unrelated volunteers for the unrelated donor registry in Argentina. The analysis characterized all HLA exons and introns for class I alleles; at least exons 2, 3 for HLA-DRB1; and exons 2 to 6 for HLA-DQB1. Of the distinct alleles present, there are 330 class I and 98 class II. The majority (~98%) of the...
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