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Article

Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence.

Science (New York, N.Y.) - 12 Jan 2018

Zhao Wenjing, Caro Florence, Robins William, Mekalanos John J

Abstract excerpt

The bacterial type VI secretion system (T6SS) is a nanomachine that delivers toxic effector proteins into target cells, killing them. In mice, we found that the Vibrio cholerae T6SS attacks members of the host commensal microbiota in vivo, facilitating the pathogen's colonization of the gut. This microbial antagonistic interaction drives measurable changes in the pathogenicity of V. cholerae through enhanced...

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Identifiers

PMID: 29326272
DOI: 10.1126/science.aap8775
PMCID: PMC8010019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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